Benefits of point-spread function and time of flight for PET/CT image quality in relation to the body mass index and injected dose

Go Akamatsu, Katsuhiko Mitsumoto, Kaori Ishikawa, Takafumi Taniguchi, Nobuyoshi Ohya, Shingo Baba, Koichiro Abe, Masayuki Sasaki

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

: The PET image quality of overweight patients and patients who receive low injected doses deteriorates because of increases in statistical noise. The purpose of this study was to investigate the benefits of the point-spread function (PSF) and time-of-flight (TOF) for PET/CT image quality in such patients. METHODS: The PET images were reconstructed using the baseline ordered-subsets expectation-maximization algorithm (OSEM), OSEM + PSF, OSEM + TOF, and OSEM + PSF + TOF. In the phantom study, we used a National Electrical Manufacturers Association body phantom with different radioactivity concentrations and analyzed image quality using the coefficient of variance in the background (CVphantom). In the clinical study, we retrospectively studied 39 patients who underwent clinical F-FDG PET/CT. The patients were classified into groups based on body mass index and injected dose. Image quality was evaluated using the CV in the liver (CVliver). RESULTS: In the phantom study, PSF and TOF improved the CVphantom, especially in low-activity models. Among all of the reconstructions, the best CVphantom was obtained with OSEM + PSF + TOF. In the clinical study, the CVliver of the low-dose group with OSEM + PSF + TOF was comparable to that of the high-dose group with conventional OSEM. CONCLUSIONS: Point-spread function and TOF improved PET/CT image quality for overweight patients who received a lower injected dose. Therefore, the use of PSF and TOF is suggested to maintain the image quality of such patients without extending scanning times. It is greatly beneficial to obtain sufficient image quality for larger patients, especially in delivery institutions where the injection dose cannot be easily increased.

本文言語英語
ページ(範囲)407-412
ページ数6
ジャーナルClinical nuclear medicine
38
6
DOI
出版ステータス出版済み - 6 2013

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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