“Benifuuki” extract reduces serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B

A double-blind placebo-controlled randomized trial

Masahiro Miyawaki, Hiroyuki Sano, Hisashi Imbe, Reiko Fujisawa, Keiji Tanimoto, Jungo Terasaki, Mari Maeda-Yamamoto, Hirofumi Tachibana, Toshiaki Hanafusa, Akihisa Imagawa

研究成果: ジャーナルへの寄稿記事

抄録

(1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O-methylated catechins in “Benifuuki” green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic; (2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of “Benifuuki” extract including 676 mg of catechins (group H), a low-dose of “Benifuuki” extract including 322 mg of catechins (group L), or no “Benifuuki” extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared; (3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol; (4) Conclusions: “Benifuuki” extract containing O-methylated catechins may help prevent arteriosclerosis.

元の言語英語
記事番号924
ジャーナルNutrients
10
発行部数7
DOI
出版物ステータス出版済み - 7 19 2018

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Class E Scavenger Receptors
apolipoprotein B
Catechin
Apolipoproteins B
low density lipoprotein
lectins
placebos
flavanols
Randomized Controlled Trials
Placebos
Ice Cream
Ligands
receptors
Arteriosclerosis
extracts
Serum
LDL Cholesterol
ice cream
low density lipoprotein cholesterol
Cholesterol

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

これを引用

“Benifuuki” extract reduces serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B : A double-blind placebo-controlled randomized trial. / Miyawaki, Masahiro; Sano, Hiroyuki; Imbe, Hisashi; Fujisawa, Reiko; Tanimoto, Keiji; Terasaki, Jungo; Maeda-Yamamoto, Mari; Tachibana, Hirofumi; Hanafusa, Toshiaki; Imagawa, Akihisa.

:: Nutrients, 巻 10, 番号 7, 924, 19.07.2018.

研究成果: ジャーナルへの寄稿記事

Miyawaki, Masahiro ; Sano, Hiroyuki ; Imbe, Hisashi ; Fujisawa, Reiko ; Tanimoto, Keiji ; Terasaki, Jungo ; Maeda-Yamamoto, Mari ; Tachibana, Hirofumi ; Hanafusa, Toshiaki ; Imagawa, Akihisa. / “Benifuuki” extract reduces serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B : A double-blind placebo-controlled randomized trial. :: Nutrients. 2018 ; 巻 10, 番号 7.
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abstract = "(1) Background: Arteriosclerosis is associated with high levels of low-density lipoprotein (LDL) cholesterol. O-methylated catechins in “Benifuuki” green tea are expected to reduce cholesterol levels, although there is limited research regarding this topic; (2) Methods: This trial evaluated 159 healthy volunteers who were randomized to receive ice cream containing a high-dose of “Benifuuki” extract including 676 mg of catechins (group H), a low-dose of “Benifuuki” extract including 322 mg of catechins (group L), or no “Benifuuki” extract (group C). Each group consumed ice cream (with or without extract) daily for 12 weeks, and their lipid-related parameters were compared; (3) Results: A significant reduction in the level of lectin-like oxidized LDL receptor-1 ligand containing ApoB (LAB) was detected in group H, compared to groups L and C. No significant differences between the three groups were detected in their levels of total cholesterol, triglycerides, and LDL cholesterol; (4) Conclusions: “Benifuuki” extract containing O-methylated catechins may help prevent arteriosclerosis.",
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AU - Tanimoto, Keiji

AU - Terasaki, Jungo

AU - Maeda-Yamamoto, Mari

AU - Tachibana, Hirofumi

AU - Hanafusa, Toshiaki

AU - Imagawa, Akihisa

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