Bilirubin, cardiovascular diseases and cancer: Epidemiological perspectives

Keizo Ohnaka, Suminori Kono

研究成果: Contribution to journalReview article査読

18 被引用数 (Scopus)

抄録

Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.

本文言語英語
ページ(範囲)891-904
ページ数14
ジャーナルExpert Review of Endocrinology and Metabolism
5
6
DOI
出版ステータス出版済み - 11 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

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