Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

Muhammad Nadeem Akhtar, Muhammad Shahid, Masaaki Sadakiyo, Muhammad Ikram, Sadia Rehman, Irshad Ahmed

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抜粋

Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

元の言語英語
ページ(範囲)272-276
ページ数5
ジャーナルPharmaceutical Chemistry Journal
51
発行部数4
DOI
出版物ステータス出版済み - 7 1 2017

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

これを引用

Akhtar, M. N., Shahid, M., Sadakiyo, M., Ikram, M., Rehman, S., & Ahmed, I. (2017). Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands. Pharmaceutical Chemistry Journal, 51(4), 272-276. https://doi.org/10.1007/s11094-017-1596-1