Biocompatibility of polyvinylalcohol gel as a vitreous substitute

Shinji Maruoka, Toyoaki Matsuura, Kensuke Kawasaki, Masahiro Okamoto, Hara Yoshiaki, Makoto Kodama, Masaaki Sugiyama, Annaka Masahiko

研究成果: ジャーナルへの寄稿記事

82 引用 (Scopus)

抄録

Polyvinylalcohol (PVA) hydrogel cross-linked by gamma irradiation was assessed as a possible vitreous substitute. From a series of experiments, rise of intraocular pressure and inflammatory changes in the vitreous cavity after operation were observed in some cases. Crab-eating macaques were used for this experiment. PVA gels were injected into vitreous cavity after vitrectomy and followed clinically by opthalmoscopy, tonometry, fundus photography, electroretinogram (ERG), chemotaxis, and flare cell meter. Histopathologic examination by light and electron microscopy was performed after 3 months. As a result, there were no significant changes in ophthalmoscopic findings. No abnormal rising of intraocular pressure (IOP) was recognized. ERG did not show meaningful amplitude weakness. From the photon counting of flare cell meter, significant break of blood-aqueous barrier and blood-retinal barrier was not observed. Histopathologic examination revealed that all layers of the retina were intact and no loss of tissue was evident. However, in PVA gel-injected eyes, some vacuolations of the inner retina were found in some specimens. To conclude, PVA gel was well tolerated in these experiments. The gel with a network similar to the vitreous body showed the best biocompatibility, though it is necessary to investigate the biocompatibility for the long-term. PVA gel is a good candidate for a vitreous substitute.

元の言語英語
ページ(範囲)599-606
ページ数8
ジャーナルCurrent Eye Research
31
発行部数7-8
DOI
出版物ステータス出版済み - 8 1 2006

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Gels
Intraocular Pressure
Retina
Blood-Aqueous Barrier
Blood-Retinal Barrier
Vitreous Body
Macaca fascicularis
Hydrogel
Photography
Vitrectomy
Manometry
Chemotaxis
Photons
Electron Microscopy
Light

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

これを引用

Maruoka, S., Matsuura, T., Kawasaki, K., Okamoto, M., Yoshiaki, H., Kodama, M., ... Masahiko, A. (2006). Biocompatibility of polyvinylalcohol gel as a vitreous substitute. Current Eye Research, 31(7-8), 599-606. https://doi.org/10.1080/02713680600813854

Biocompatibility of polyvinylalcohol gel as a vitreous substitute. / Maruoka, Shinji; Matsuura, Toyoaki; Kawasaki, Kensuke; Okamoto, Masahiro; Yoshiaki, Hara; Kodama, Makoto; Sugiyama, Masaaki; Masahiko, Annaka.

:: Current Eye Research, 巻 31, 番号 7-8, 01.08.2006, p. 599-606.

研究成果: ジャーナルへの寄稿記事

Maruoka, S, Matsuura, T, Kawasaki, K, Okamoto, M, Yoshiaki, H, Kodama, M, Sugiyama, M & Masahiko, A 2006, 'Biocompatibility of polyvinylalcohol gel as a vitreous substitute', Current Eye Research, 巻. 31, 番号 7-8, pp. 599-606. https://doi.org/10.1080/02713680600813854
Maruoka S, Matsuura T, Kawasaki K, Okamoto M, Yoshiaki H, Kodama M その他. Biocompatibility of polyvinylalcohol gel as a vitreous substitute. Current Eye Research. 2006 8 1;31(7-8):599-606. https://doi.org/10.1080/02713680600813854
Maruoka, Shinji ; Matsuura, Toyoaki ; Kawasaki, Kensuke ; Okamoto, Masahiro ; Yoshiaki, Hara ; Kodama, Makoto ; Sugiyama, Masaaki ; Masahiko, Annaka. / Biocompatibility of polyvinylalcohol gel as a vitreous substitute. :: Current Eye Research. 2006 ; 巻 31, 番号 7-8. pp. 599-606.
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