Biofunctionality of self-assembled nanolayers composed of cellulosic polymers

研究成果: Contribution to journalArticle査読

26 被引用数 (Scopus)

抄録

Biofunctional cellulosic interfaces were successfully designed via the self-assembly of cellulose and its derivatives whose reducing ends were selectively modified with thiosemicarbazide. The biological functions of cellulosic self-assembled monolayers (SAMs) formed on a gold surface were investigated using rat liver cells. The cells proliferated well on the cellulose SAM (cellulose I) and methylcellulose SAM, while almost no cells adhered to the regenerated cellulose film (cellulose II) and hydroxyethylcellulose SAM. In the initial cell adhesion, rat liver cells were moderately attached on the cellulose SAM even in serum-free culture, possibly suggesting specific interactions between cells and cellulose SAM with unique surface morphology. The architectural design of cellulosic nanolayers via peculiar vectorial chain immobilization is expected to provide new information for the functional development of structural polysaccharide-based biointerfaces.

本文言語英語
ページ(範囲)666-672
ページ数7
ジャーナルCarbohydrate Polymers
74
3
DOI
出版ステータス出版済み - 11 4 2008

All Science Journal Classification (ASJC) codes

  • 有機化学
  • ポリマーおよびプラスチック
  • 材料化学

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