Bioinspired Perfluorocarbon-Based Oxygen Carriers with Concave Shape and Deformable Shell

Xiaoting Fu, Seiichi Ohta, Takahiro Kawakatsu, Masamichi Kamihira, Yasuyuki Sakai, Taichi Ito

研究成果: Contribution to journalArticle査読

抄録

Human red blood cells (hRBCs) possess a unique biconcave structure with a highly deformable cell membrane and condensed cytosol hemoglobin for oxygen delivery. Inspired by hRBCs, novel deformable core-shell particles are developed as perfluorocarbon-based oxygen carriers (OCs), called “cDFCs” (concave-shaped deformable PFC-based OCs), using the Shirasu porous glass (SPG) membrane emulsification technique. cDFCs have a perfluorooctyl bromide core of high oxygen solubility and poly(lactide-co-caprolactone) shell, which is thin and highly deformable. They have an optical equivalent diameter of 7.9 ± 2.5 µm and a unique concave shape. Owing to their low Young's modulus (93 kPa) and their diameter and shape, they successfully pass through a 4.5-µm-gap silicon microchannel as a blood capillary model. Enhanced oxygen supply to multiple layered cells is demonstrated under hypoxic conditions, indicating their efficiency as OCs. cDFCs are new potential OCs in tissue engineering and blood substitution in the future.

本文言語英語
ジャーナルAdvanced Materials Technologies
DOI
出版ステータス受理済み/印刷中 - 2021

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 材料力学
  • 産業および生産工学

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