Biological features determining the chemosensitivity of gastric cancer

Y. Ichiyoshi, K. Endo, M. Yamamoto, Y. Maehara, K. Sugimachi

研究成果: Contribution to journalReview article査読


We analysed the relationship between several biological properties of gastric cancers and their chemosensitivity determined by MTT assay. Higher chemosensitivity was associated with poor differentiation, aneuploidy, and higher proliferative activity. Lymph node metastasis was more chemosensitive than primary lesion, while liver metastasis was less. Gastric cancer expressing multidrug-resistance associated protein (MRP) showed lower sensitivity to several anticancer drugs, including adriamycin and etoposide. p53 status and susceptibility to apoptosis were also associated with chemosensitivity. Thus, chemosensitivity of clinical gastric cancer might be increased if these characters can be modified by some new biologic therapy.

ジャーナルHuman cell : official journal of Human Cell Research Society
出版ステータス出版済み - 12 1995

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Cancer Research

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