Biologically active glycosides from asteroidea, 43. Isolation and structure of a new neuritogenic-active ganglioside molecular species from the starfish Linckia laevigata

Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抜粋

A ganglioside molecular species, LLG-5 (1), has been obtained from the water soluble lipid fraction of the CHCl3/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. 1 is a new ganglioside molecular species possessing a 2→11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochromocytoma PC-12 cells in the presence of nerve growth factor.

元の言語英語
ページ(範囲)1551-1554
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
53
発行部数12
DOI
出版物ステータス出版済み - 12 2005

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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