Biologically active glycosides from asteroidea, 43. Isolation and structure of a new neuritogenic-active ganglioside molecular species from the starfish Linckia laevigata

Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

A ganglioside molecular species, LLG-5 (1), has been obtained from the water soluble lipid fraction of the CHCl3/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. 1 is a new ganglioside molecular species possessing a 2→11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochromocytoma PC-12 cells in the presence of nerve growth factor.

本文言語英語
ページ(範囲)1551-1554
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
53
12
DOI
出版ステータス出版済み - 12月 2005

!!!All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 創薬

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