Biomimetic synthesis of α-amino acids from α-keto acids

Seiji Shinkai; Hisatake Hamada; Akihiko Dohyama; Osamu Manabe

doi:10.1016/S0040-4039(00)77779-3

Biomimetic synthesis of α-amino acids from α-keto acids

Seiji Shinkai, Hisatake Hamada, Akihiko Dohyama, Osamu Manabe

研究成果: Contribution to journal › Article › 査読

14 被引用数 (Scopus)

抄録

Protonated α-imino acids, RC(=NH₂⁺)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

本文言語	英語
ページ（範囲）	1661-1664
ページ数	4
ジャーナル	Tetrahedron Letters
巻	21
号	17
DOI	https://doi.org/10.1016/S0040-4039(00)77779-3
出版ステータス	出版済み - 1 1 1980
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

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10.1016/S0040-4039(00)77779-3

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引用スタイル

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title = "Biomimetic synthesis of α-amino acids from α-keto acids",

abstract = "Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.",

author = "Seiji Shinkai and Hisatake Hamada and Akihiko Dohyama and Osamu Manabe",

year = "1980",

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N2 - Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

AB - Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

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JF - Tetrahedron Letters

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Biomimetic synthesis of α-amino acids from α-keto acids

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