Biosynthetic mechanism for L-gulose in main polar lipids of thermoplasma acidophilum and possible resemblance to plant ascorbic acid biosynthesis

Noriaki Yamauchi, Yusuke Nakayama

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

L-Gulose is a very rare sugar, but appears as a sugar component of the main polar lipids characteristic in such a thermophilic archaeon as Thermoplasma acidophilum that lives without cell walls in a highly acidic environment. The biosynthesis of L-gulose in this thermophilic organism was investigated with deuterium- labeling experiments. L-Gulose was found to be biosynthesized from D-glucose via stepwise stereochemical inversion at C-2 and C-5. The involvement of an epimerase related to GDP-mannose 3,5-epimerase, the key enzyme of plant ascorbate biosynthesis, was also suggested in this C-5 inversion. The resemblance of Lgulose biosynthesis in archaea and plants might be suggested from these results.

本文言語英語
ページ(範囲)2087-2093
ページ数7
ジャーナルBioscience, Biotechnology and Biochemistry
77
10
DOI
出版ステータス出版済み - 11 4 2013

All Science Journal Classification (ASJC) codes

  • 分析化学
  • バイオテクノロジー
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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