Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour; Saleh El-Sharkawy; Mohamed Amer; Fatma Abdel Bar; Amira Mera; Toshiro Nagata; Ryuichiro Kondo; Kuniyoshi Shimizu

doi:10.2174/1874847320130628001

Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour, Saleh El-Sharkawy, Mohamed Amer, Fatma Abdel Bar, Amira Mera, Toshiro Nagata, Ryuichiro Kondo, Kuniyoshi Shimizu

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

2 被引用数 (Scopus)

抄録

Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

本文言語	英語
ページ（範囲）	1-3
ページ数	3
ジャーナル	Open Bioactive Compounds Journal
巻	4
DOI	https://doi.org/10.2174/1874847320130628001
出版ステータス	出版済み - 2013

!!!All Science Journal Classification (ASJC) codes

創薬
薬科学
分子医療
分子生物学
生化学
薬理学

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10.2174/1874847320130628001

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title = "Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities",

abstract = "Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.",

author = "Ahmed Ashour and Saleh El-Sharkawy and Mohamed Amer and Bar, {Fatma Abdel} and Amira Mera and Toshiro Nagata and Ryuichiro Kondo and Kuniyoshi Shimizu",

year = "2013",

doi = "10.2174/1874847320130628001",

language = "English",

volume = "4",

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TY - JOUR

T1 - Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

AU - Ashour, Ahmed

AU - El-Sharkawy, Saleh

AU - Amer, Mohamed

AU - Bar, Fatma Abdel

AU - Mera, Amira

AU - Nagata, Toshiro

AU - Kondo, Ryuichiro

AU - Shimizu, Kuniyoshi

PY - 2013

Y1 - 2013

N2 - Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

AB - Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

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DO - 10.2174/1874847320130628001

M3 - Article

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SN - 1874-8473

VL - 4

SP - 1

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JO - Open Bioactive Compounds Journal

JF - Open Bioactive Compounds Journal

ER -

Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

抄録

!!!All Science Journal Classification (ASJC) codes

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