Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour, Saleh El-Sharkawy, Mohamed Amer, Fatma Abdel Bar, Amira Mera, Toshiro Nagata, Ryuichiro Kondo, Kuniyoshi Shimizu

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

本文言語英語
ページ(範囲)1-3
ページ数3
ジャーナルOpen Bioactive Compounds Journal
4
DOI
出版ステータス出版済み - 2013

All Science Journal Classification (ASJC) codes

  • 創薬
  • 薬科学
  • 分子医療
  • 分子生物学
  • 生化学
  • 薬理学

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