Biphasic forearm vascular responses to intraarterial arginine vasopressin

S. Suzuki, A. Takeshita, T. Imaizumi, Y. Hirooka, M. Yoshida, S. Ando, M. Nakamura

    研究成果: Contribution to journalArticle査読

    43 被引用数 (Scopus)

    抄録

    Forearm vascular responses to arginine vasopressin (AVP) infused into a brachial artery in a wide range of infusion rates (0.05-2.0 ng/kg per min) were examined in 20 young healthy volunteers. Intraarterial AVP at lower doses (0.05 and 0.1 ng/kg per min) caused forearm vasoconstriction, whereas AVP at a dose of 0.2 ng/kg per min or higher caused forearm vasodilatation. The maximal forearm vasoconstriction was induced at the venous plasma AVP level of 76.3 ± 8.8 pg/ml. Forearm vasodilatation was associated with the venous plasma VP level of 369 ± 43 pg/ml or higher. Forearm vasodilatation was the result of the direct effect of AVP since forearm blood flow and vascular resistance in the contralateral arm did not change. We attempted to explore the mechanisms involved in AVP-induced direct vasodilatation. The treatment with indomethacin, 75 mg/d for 3 d, did not alter AVP-induced forearm vasodilatation. In contrast, intraarterial infusion of isoosmolar CaCl2 totally prevented AVP-induced forearm vasodilatation. Intraarterial CaCl2 also markedly attenuated forearm vasodilatation induced by intraarterial sodium nitroprusside, but did not alter forearm vasodilatation induced by intraarterial isoproterenol. These results indicate that the direct vascular effects of intraarterial AVP on the forearm vessels are biphasic, causing vasoconstriction at lower doses and vasodilatation at higher doses. The direct vasodilatation induced by intraarterial AVP at higher doses is not mediated by prostaglandins but may involve cGMP-related mechanisms.

    本文言語英語
    ページ(範囲)427-434
    ページ数8
    ジャーナルJournal of Clinical Investigation
    84
    2
    DOI
    出版ステータス出版済み - 1989

    All Science Journal Classification (ASJC) codes

    • 医学(全般)

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