Bipolar disorder

Bipolar disorder (BD) is a common psychiatric condition that is associated with a diverse range of symptoms across several domains. While the core feature is disturbance in mood states, disruption of biological rhythms, energy behavior, and cognition is central to its impact on functioning in daily life. Diagnosis requires knowledge about an individual’s episodes of distinctly elevated mood: mania for type I BD and hypomania for type II. Defining the nature of BD has always been something of a challenge for psychiatrists, and, thus, establishing a neurobiological model of the condition has been a matter of long debate. This overview of magnetoencephalographic (MEG) studies that investigated BD describes event-related responses related to auditory function such as M50, M100, M200, MMNm, and neural oscillations. Based on our review, auditory dysfunctions in BD are outlined, and interpretations are delivered in light of recent developments in the field of clinical neurophysiology. Thus, we lead clinicians and researchers through some of the more actively debated topics regarding BD research and its potential direction in the future.