TY - JOUR
T1 - Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus
AU - Sakuda, S.
AU - Ono, M.
AU - Ikeda, H.
AU - Nakamura, T.
AU - Inagaki, Y.
AU - Kawachi, R.
AU - Nakayama, J.
AU - Suzuki, A.
AU - Isogai, A.
AU - Nagasawa, H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.
AB - Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.
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U2 - 10.7164/antibiotics.53.1265
DO - 10.7164/antibiotics.53.1265
M3 - Article
C2 - 11213287
AN - SCOPUS:0033676338
SN - 0021-8820
VL - 53
SP - 1265
EP - 1271
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 11
ER -