Blind spot of G1/S checkpoint: G1/S checkpoint is invaded by DNA-damage after R-point

Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Yukihiro Eguchi

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

The transition from G1 phase to S phase in the cell cycle is regulated by G1/S checkpoint, which can arrest the G1 progression when DNA-damage occurred. However, it was reported that G1 arrest was not induced when DNA-damage occurred at late G1 phase. This finding implies that G1/S checkpoint cannot detect the DNA-damage on late G1 phase. The inadequate regulation of G1/S checkpoint to cell cycle progression produces serious effects on both the cellular homeostasis and genetic stability. In this paper, to verify the inadequate regulation of G1/S checkpoint, we constructed a novel mathematical model (proposed model), which integrated G1/S checkpoint with p53-dependent DNA-damage pathway, and simulated a dynamic behavior of G1/S transition involving DNA-damage. The hot issue of the study is that the simulation results of the proposed model with/without DNA-damage can qualitatively realize the biological findings such that G1/S checkpoint cannot detect the DNA-damage on late G1 phase.

本文言語英語
ホスト出版物のタイトルIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
ページ241-246
ページ数6
出版ステータス出版済み - 2008
イベントIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008 - Orlando, FL, 米国
継続期間: 11 16 200811 18 2008

出版物シリーズ

名前IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008

その他

その他IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
Country米国
CityOrlando, FL
Period11/16/0811/18/08

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Biomedical Engineering
  • Health Informatics

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