Blockade of androgen-induced malignant phenotypes by flutamide administration in human salivary duct carcinoma cells

Yu Kamata, Tomoki Sumida, Ryuichi Murase, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5α-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC.

元の言語英語
ページ(範囲)6071-6075
ページ数5
ジャーナルAnticancer Research
36
発行部数11
DOI
出版物ステータス出版済み - 11 1 2016

Fingerprint

Salivary Ducts
Flutamide
Androgens
Carcinoma
Phenotype
Dihydrotestosterone
Androgen Receptors
Cell Movement
Salivary Gland Neoplasms
Wound Healing
Prostatic Neoplasms
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Blockade of androgen-induced malignant phenotypes by flutamide administration in human salivary duct carcinoma cells. / Kamata, Yu; Sumida, Tomoki; Murase, Ryuichi; Nakano, Hiroyuki; Yamada, Tomohiro; Mori, Yoshihide.

:: Anticancer Research, 巻 36, 番号 11, 01.11.2016, p. 6071-6075.

研究成果: ジャーナルへの寄稿記事

@article{4b5ba971b25a41ab989e36cfa98c4489,
title = "Blockade of androgen-induced malignant phenotypes by flutamide administration in human salivary duct carcinoma cells",
abstract = "Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5α-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC.",
author = "Yu Kamata and Tomoki Sumida and Ryuichi Murase and Hiroyuki Nakano and Tomohiro Yamada and Yoshihide Mori",
year = "2016",
month = "11",
day = "1",
doi = "10.21873/anticanres.11196",
language = "English",
volume = "36",
pages = "6071--6075",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "11",

}

TY - JOUR

T1 - Blockade of androgen-induced malignant phenotypes by flutamide administration in human salivary duct carcinoma cells

AU - Kamata, Yu

AU - Sumida, Tomoki

AU - Murase, Ryuichi

AU - Nakano, Hiroyuki

AU - Yamada, Tomohiro

AU - Mori, Yoshihide

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5α-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC.

AB - Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5α-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC.

UR - http://www.scopus.com/inward/record.url?scp=84993999947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84993999947&partnerID=8YFLogxK

U2 - 10.21873/anticanres.11196

DO - 10.21873/anticanres.11196

M3 - Article

VL - 36

SP - 6071

EP - 6075

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 11

ER -