Blood pressure control in a japanese population with chronic kidney disease: A baseline survey of a nationwide cohort

Tsuneo Konta, Ami Ikeda, Kazunobu Ichikawa, Shouichi Fujimoto, Kunitoshi Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Hideaki Yoshida, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Background Hypertension is a key risk factor for adverse renal outcomes in chronic kidney disease (CKD), and strict blood pressure control is recommended to halt its progression. This study assessed blood pressure control in the Japanese CKD population. Methods We used a nationwide database of 250,130 subjects (aged 20-88), including 45,845 CKD subjects (18.3%), participated in an annual health check, The Specific Health Check and Guidance in Japan, and examined the relationship between CKD status and blood pressure. Blood pressures were measured in sitting position by trained staff, and target blood pressure for CKD subjects was defined as systolic (SBP)/diastolic blood pressure (DBP) <130/80mmHg. Results In total population, CKD subjects had a higher prevalence of hypertension (58.0% vs. 41.8%, P< 0.001) and a higher proportion with antihypertensive medication (42.4% vs. 26.7%, P< 0.001), compared with non-CKD subjects. The proportion of subjects achieving target blood pressure was significantly lower among total CKD subjects than among total non-CKD subjects (34.6% vs. 43.8%, P≤ 0.001). Among CKD subjects, these proportions were especially low in those with stage 4-5 (24.3-27.5%), those on antihypertensive medication (21.6%) and those with proteinuria ≥2±(21.3%). Logistic regression analysis showed that independent factors for high-blood pressure in CKD subjects were age, male gender, alcohol consumption, nonsmoking, diabetes, dyslipidemia, obesity, proteinuria, and antihypertensive medication. Conclusions Blood pressure control was inadequate in the majority of Japanese CKD subjects, despite antihypertensive treatment. More aggressive efforts to achieve target blood pressures among CKD subjects are recommended.

元の言語英語
ページ(範囲)342-347
ページ数6
ジャーナルAmerican Journal of Hypertension
25
発行部数3
DOI
出版物ステータス出版済み - 3 1 2012

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Chronic Renal Insufficiency
Blood Pressure
Population
Antihypertensive Agents
Kidney Diseases
Hypertension
Proteinuria
Surveys and Questionnaires
Health
Dyslipidemias
Posture
Alcohol Drinking
Japan
Obesity
Logistic Models
Regression Analysis
Databases
Kidney

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Blood pressure control in a japanese population with chronic kidney disease : A baseline survey of a nationwide cohort. / Konta, Tsuneo; Ikeda, Ami; Ichikawa, Kazunobu; Fujimoto, Shouichi; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Tsuruya, Kazuhiko; Yoshida, Hideaki; Asahi, Koichi; Kurahashi, Issei; Ohashi, Yasuo; Watanabe, Tsuyoshi.

:: American Journal of Hypertension, 巻 25, 番号 3, 01.03.2012, p. 342-347.

研究成果: ジャーナルへの寄稿記事

Konta, T, Ikeda, A, Ichikawa, K, Fujimoto, S, Iseki, K, Moriyama, T, Yamagata, K, Tsuruya, K, Yoshida, H, Asahi, K, Kurahashi, I, Ohashi, Y & Watanabe, T 2012, 'Blood pressure control in a japanese population with chronic kidney disease: A baseline survey of a nationwide cohort', American Journal of Hypertension, 巻. 25, 番号 3, pp. 342-347. https://doi.org/10.1038/ajh.2011.217
Konta, Tsuneo ; Ikeda, Ami ; Ichikawa, Kazunobu ; Fujimoto, Shouichi ; Iseki, Kunitoshi ; Moriyama, Toshiki ; Yamagata, Kunihiro ; Tsuruya, Kazuhiko ; Yoshida, Hideaki ; Asahi, Koichi ; Kurahashi, Issei ; Ohashi, Yasuo ; Watanabe, Tsuyoshi. / Blood pressure control in a japanese population with chronic kidney disease : A baseline survey of a nationwide cohort. :: American Journal of Hypertension. 2012 ; 巻 25, 番号 3. pp. 342-347.
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title = "Blood pressure control in a japanese population with chronic kidney disease: A baseline survey of a nationwide cohort",
abstract = "Background Hypertension is a key risk factor for adverse renal outcomes in chronic kidney disease (CKD), and strict blood pressure control is recommended to halt its progression. This study assessed blood pressure control in the Japanese CKD population. Methods We used a nationwide database of 250,130 subjects (aged 20-88), including 45,845 CKD subjects (18.3{\%}), participated in an annual health check, The Specific Health Check and Guidance in Japan, and examined the relationship between CKD status and blood pressure. Blood pressures were measured in sitting position by trained staff, and target blood pressure for CKD subjects was defined as systolic (SBP)/diastolic blood pressure (DBP) <130/80mmHg. Results In total population, CKD subjects had a higher prevalence of hypertension (58.0{\%} vs. 41.8{\%}, P< 0.001) and a higher proportion with antihypertensive medication (42.4{\%} vs. 26.7{\%}, P< 0.001), compared with non-CKD subjects. The proportion of subjects achieving target blood pressure was significantly lower among total CKD subjects than among total non-CKD subjects (34.6{\%} vs. 43.8{\%}, P≤ 0.001). Among CKD subjects, these proportions were especially low in those with stage 4-5 (24.3-27.5{\%}), those on antihypertensive medication (21.6{\%}) and those with proteinuria ≥2±(21.3{\%}). Logistic regression analysis showed that independent factors for high-blood pressure in CKD subjects were age, male gender, alcohol consumption, nonsmoking, diabetes, dyslipidemia, obesity, proteinuria, and antihypertensive medication. Conclusions Blood pressure control was inadequate in the majority of Japanese CKD subjects, despite antihypertensive treatment. More aggressive efforts to achieve target blood pressures among CKD subjects are recommended.",
author = "Tsuneo Konta and Ami Ikeda and Kazunobu Ichikawa and Shouichi Fujimoto and Kunitoshi Iseki and Toshiki Moriyama and Kunihiro Yamagata and Kazuhiko Tsuruya and Hideaki Yoshida and Koichi Asahi and Issei Kurahashi and Yasuo Ohashi and Tsuyoshi Watanabe",
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T1 - Blood pressure control in a japanese population with chronic kidney disease

T2 - A baseline survey of a nationwide cohort

AU - Konta, Tsuneo

AU - Ikeda, Ami

AU - Ichikawa, Kazunobu

AU - Fujimoto, Shouichi

AU - Iseki, Kunitoshi

AU - Moriyama, Toshiki

AU - Yamagata, Kunihiro

AU - Tsuruya, Kazuhiko

AU - Yoshida, Hideaki

AU - Asahi, Koichi

AU - Kurahashi, Issei

AU - Ohashi, Yasuo

AU - Watanabe, Tsuyoshi

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Background Hypertension is a key risk factor for adverse renal outcomes in chronic kidney disease (CKD), and strict blood pressure control is recommended to halt its progression. This study assessed blood pressure control in the Japanese CKD population. Methods We used a nationwide database of 250,130 subjects (aged 20-88), including 45,845 CKD subjects (18.3%), participated in an annual health check, The Specific Health Check and Guidance in Japan, and examined the relationship between CKD status and blood pressure. Blood pressures were measured in sitting position by trained staff, and target blood pressure for CKD subjects was defined as systolic (SBP)/diastolic blood pressure (DBP) <130/80mmHg. Results In total population, CKD subjects had a higher prevalence of hypertension (58.0% vs. 41.8%, P< 0.001) and a higher proportion with antihypertensive medication (42.4% vs. 26.7%, P< 0.001), compared with non-CKD subjects. The proportion of subjects achieving target blood pressure was significantly lower among total CKD subjects than among total non-CKD subjects (34.6% vs. 43.8%, P≤ 0.001). Among CKD subjects, these proportions were especially low in those with stage 4-5 (24.3-27.5%), those on antihypertensive medication (21.6%) and those with proteinuria ≥2±(21.3%). Logistic regression analysis showed that independent factors for high-blood pressure in CKD subjects were age, male gender, alcohol consumption, nonsmoking, diabetes, dyslipidemia, obesity, proteinuria, and antihypertensive medication. Conclusions Blood pressure control was inadequate in the majority of Japanese CKD subjects, despite antihypertensive treatment. More aggressive efforts to achieve target blood pressures among CKD subjects are recommended.

AB - Background Hypertension is a key risk factor for adverse renal outcomes in chronic kidney disease (CKD), and strict blood pressure control is recommended to halt its progression. This study assessed blood pressure control in the Japanese CKD population. Methods We used a nationwide database of 250,130 subjects (aged 20-88), including 45,845 CKD subjects (18.3%), participated in an annual health check, The Specific Health Check and Guidance in Japan, and examined the relationship between CKD status and blood pressure. Blood pressures were measured in sitting position by trained staff, and target blood pressure for CKD subjects was defined as systolic (SBP)/diastolic blood pressure (DBP) <130/80mmHg. Results In total population, CKD subjects had a higher prevalence of hypertension (58.0% vs. 41.8%, P< 0.001) and a higher proportion with antihypertensive medication (42.4% vs. 26.7%, P< 0.001), compared with non-CKD subjects. The proportion of subjects achieving target blood pressure was significantly lower among total CKD subjects than among total non-CKD subjects (34.6% vs. 43.8%, P≤ 0.001). Among CKD subjects, these proportions were especially low in those with stage 4-5 (24.3-27.5%), those on antihypertensive medication (21.6%) and those with proteinuria ≥2±(21.3%). Logistic regression analysis showed that independent factors for high-blood pressure in CKD subjects were age, male gender, alcohol consumption, nonsmoking, diabetes, dyslipidemia, obesity, proteinuria, and antihypertensive medication. Conclusions Blood pressure control was inadequate in the majority of Japanese CKD subjects, despite antihypertensive treatment. More aggressive efforts to achieve target blood pressures among CKD subjects are recommended.

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