BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Jun Kohyama, Tsukasa Sanosaka, Akinori Tokunaga, Eriko Takatsuka, Keita Tsujimura, Hideyuki Okano, Kinichi Nakashima

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

抄録

Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation remains unclear. In the mammalian central nervous system, neurons, astrocytes, and oligodendrocytes are generated throughout life from common tripotent neural progenitor cells (NPCs). Bone morphogenetic proteins (BMPs) are well-known astrocyte-inducing cytokines. We show here that the expression of a transcriptional repressor, REl silencer of transcription (RESTJ/neuron- restrictive silencer factor (NRSF), is up-regulated and sustained by BMP signal activation in the course of astrocytic differentiation of NPCs, and restricts neuronal differentiation. We further show that, in differentiated astrocytes, endogenous REST/ NRSF associates with various neuronal genes and that disruption of its function resulted in their derepression, thereby explaining how ectopic neuronal gene expression is prevented in cells with astrocytic traits. Collectively, our results suggest that REST/NRSF functions as a molecular regulator of the nonneuronal phenotype in astrocytes.

元の言語英語
ページ(範囲)159-170
ページ数12
ジャーナルJournal of Cell Biology
189
発行部数1
DOI
出版物ステータス出版済み - 4 5 2010

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Bone Morphogenetic Proteins
Astrocytes
Maintenance
Stem Cells
Oligodendroglia
Cell Lineage
Genes
Central Nervous System
Cytokines
Phenotype
Neurons
RE1-silencing transcription factor

All Science Journal Classification (ASJC) codes

  • Cell Biology

これを引用

Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H., & Nakashima, K. (2010). BMP-induced REST regulates the establishment and maintenance of astrocytic identity. Journal of Cell Biology, 189(1), 159-170. https://doi.org/10.1083/jcb.200908048

BMP-induced REST regulates the establishment and maintenance of astrocytic identity. / Kohyama, Jun; Sanosaka, Tsukasa; Tokunaga, Akinori; Takatsuka, Eriko; Tsujimura, Keita; Okano, Hideyuki; Nakashima, Kinichi.

:: Journal of Cell Biology, 巻 189, 番号 1, 05.04.2010, p. 159-170.

研究成果: ジャーナルへの寄稿記事

Kohyama, J, Sanosaka, T, Tokunaga, A, Takatsuka, E, Tsujimura, K, Okano, H & Nakashima, K 2010, 'BMP-induced REST regulates the establishment and maintenance of astrocytic identity', Journal of Cell Biology, 巻. 189, 番号 1, pp. 159-170. https://doi.org/10.1083/jcb.200908048
Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H その他. BMP-induced REST regulates the establishment and maintenance of astrocytic identity. Journal of Cell Biology. 2010 4 5;189(1):159-170. https://doi.org/10.1083/jcb.200908048
Kohyama, Jun ; Sanosaka, Tsukasa ; Tokunaga, Akinori ; Takatsuka, Eriko ; Tsujimura, Keita ; Okano, Hideyuki ; Nakashima, Kinichi. / BMP-induced REST regulates the establishment and maintenance of astrocytic identity. :: Journal of Cell Biology. 2010 ; 巻 189, 番号 1. pp. 159-170.
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