Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice

Tomoyuki Akashi, Hirokazu Shigematsu, Yoshiyuki Hamamoto, Hiromi Iwasaki, Shigeru Yatoh, Susan Bonner-Weir, Koichi Akashi, Gordon C. Weir

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Background: In this study, we carried out bone marrow and foetal liver cell transplantation to determine if these cells could differentiate into pancreatic β-cells or promote regeneration. Methods: To exclude an artificial or immunological influence for induction of diabetes to recipients, Akita mice, which develop diabetes spontaneously, were used. In addition, we used mice harbouring the transgenic green fluorescent protein (GFP) reporter for insulin 1 gene as donors to mark donor-derived β-cells. Results: All transplanted Akita mice after intravenous injection showed full donor chimerism in peripheral blood analysis. Their diabetic state represented by blood glucose levels did not change after transplantation. In spite of examination of more than 200 islets in each group, we could not find GFP-positive cells in any of the recipients. Conclusions: Bone marrow cells or foetal liver cells do not differentiate to new pancreatic β-cells or promote regeneration in Akita mice, a non-chemical or non-immune model of diabetes.

本文言語英語
ページ(範囲)585-590
ページ数6
ジャーナルDiabetes/Metabolism Research and Reviews
24
7
DOI
出版ステータス出版済み - 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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