Bone marrow stroma cells are susceptible to prion infection

Yuka Takakura, Naohiro Yamaguchi, Takehiro Nakagaki, Katsuya Satoh, Jun ichi Kira, Noriyuki Nishida

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Abnormal protease-resistant prion protein (PrP-res) is the only surrogate biochemical marker for prion diseases, and a sensitive technique to detect PrP-res in blood or tissues is urgently needed. Primary cultured bone marrow stromal cells (MSCs) expressed PrP and were capable of supporting stable human prion infection. Using a mouse-adapted BSE strain, we demonstrated that PrP-res can be detected in expanded MSCs. We then analyzed the bone marrow cells collected at autopsy from two individuals with sporadic Creutzfeldt-Jakob disease (CJD), and, in both cases, cultured MSCs were positive for PrP-res. These data would suggest that ex vivo MSC expansion accompanied by PrP-res analysis could be a helpful tool in the definitive diagnosis of prion disease at an earlier stage in the disease process than is currently possible, and with considerably less distress to the patient.

本文言語英語
ページ(範囲)957-961
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
377
3
DOI
出版ステータス出版済み - 12 19 2008

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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