抄録
We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 625-632 |
| ページ数 | 8 |
| ジャーナル | Journal of Biomedical Materials Research - Part A |
| 巻 | 108 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 受理済み/印刷中 - 1 1 2019 |
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All Science Journal Classification (ASJC) codes
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys
これを引用
Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules. / Putri, Tansza S.; Hayashi, Koichiro; Ishikawa, Kunio.
：: Journal of Biomedical Materials Research - Part A, 巻 108, 番号 3, 01.03.2020, p. 625-632.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules
AU - Putri, Tansza S.
AU - Hayashi, Koichiro
AU - Ishikawa, Kunio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.
AB - We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.
UR - http://www.scopus.com/inward/record.url?scp=85076134121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85076134121&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.36842
DO - 10.1002/jbm.a.36842
M3 - Article
C2 - 31742920
AN - SCOPUS:85076134121
VL - 108
SP - 625
EP - 632
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 1549-3296
IS - 3
ER -