Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules

研究成果: ジャーナルへの寄稿記事

抄録

We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.

元の言語英語
ページ(範囲)625-632
ページ数8
ジャーナルJournal of Biomedical Materials Research - Part A
108
発行部数3
DOI
出版物ステータス受理済み/印刷中 - 1 1 2019

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Bone
Phosphates
Bone Substitutes
Defects
Tensile strength
Porosity
tricalcium phosphate

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

これを引用

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title = "Bone regeneration using β-tricalcium phosphate (β-TCP) block with interconnected pores made by setting reaction of β-TCP granules",
abstract = "We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7{\%} and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1{\%} of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1{\%}), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1{\%} was resorbed, and the amount of new bone was 18.9 ± 5.5{\%}. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.",
author = "Putri, {Tansza S.} and Koichiro Hayashi and Kunio Ishikawa",
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AB - We fabricated an interconnected dual porous β-tricalcium phosphate (β-TCP) block via a setting reaction of β-TCP granules. This β-TCP block was unique because it exhibits a fully interconnected macroporous structure with micropores in the walls surrounding macropores and a roughened surface. The porosity and diametral tensile strength of the resulting product were 58.1 ± 1.7% and 1.4 ± 0.2 MPa, respectively. Rabbit distal femur bone defects were reconstructed using the porous β-TCP block and the efficacy of the porous β-TCP block as an artificial bone substitute was evaluated histomorphometrically. For a dense β-TCP control, 4 weeks following implantation, only 0.2 ± 0.1% of the β-TCP was resorbed, and the amount of newly formed bone was limited (0.1 ± 0.1%), whereas when the defect was reconstructed with porous β-TCP, 9.2 ± 3.1% was resorbed, and the amount of new bone was 18.9 ± 5.5%. This represents an approximately 50-fold enhancement in resorption and a 200-fold increase in bone formation for our porous β-TCP block. Therefore, interconnected dual porous β-TCP made via β-TCP granule setting has good potential as an artificial bone substitute.

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