Both the HLA-DPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese: Clinical phenotypes and gender as important factors

Toshiyuki Fukazawa, K. Yamasaki, H. Ito, S. Kikuchi, M. Minohara, I. Horiuchi, E. Tsukishima, H. Sasaki, T. Hamada, Y. Nishimura, K. Tashiro, J. Kira

研究成果: Contribution to journalArticle査読

66 被引用数 (Scopus)

抄録

The purpose of this study was to clarify the association of HLA-DRB1 and -DPB1 alleles with multiple sclerosis (MS) in Japanese, to determine whether optico-spinal MS (OS-MS) and conventional MS are immunogenetically distinct, and to verify the role of gender difference in HLA associations of MS. We studied HLA-DRB1 and -DPB1 polymorphisms in 166 Japanese patients with MS. Forty-seven patients were classified as having the optico-spinal MS (OS-MS) and 119 as having conventional MS. A lack of DPB1*0301 and a higher frequency of DPB1*0501 compared with controls (corrected P < 0.0074; odds ratio = 9.48) were found in OS-MS. By contrast, we found for the first time an association of DPB1*0301 with conventional MS in Japanese (corrected P = 0.0444; odds ratio = 3.28). Logistic analysis, adjusted for sex and age, revealed independent associations of DPB1*0301 (P = 0.0004, adjusted odds ratio (aOR) = 4.70), DPB1*0501 (P = 0.0081, aOR = 2.50) and DRB1*1501 (P = 0.0252, aOR = 2.21) with conventional MS. However, the frequencies of DRB1*1501 and DPB1*0501 in male patients with conventional MS were equal to those in male controls while the DPB1*0301 frequency was increased in both male and female patients. We did not find any association of these HLA alleles with disease course and severity. In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS.

本文言語英語
ページ(範囲)199-205
ページ数7
ジャーナルTissue antigens
55
3
DOI
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 生化学
  • 遺伝学

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