Bradykinin mediates, the acute effect of an angiotensin-converting enzyme inhibitor on cerebral autoregulation in rats

Junichi Takada, Setsuro Ibayashi, Tetsuhiko Nagao, Hiroaki Ooboshi, Takanari Kitazono, Masatoshi Fujishima

研究成果: Contribution to journalArticle査読

21 被引用数 (Scopus)

抄録

Background and Purpose - In patients with stroke and long-standing hypertension, the autoregulation curve of cerebral blood flow (CBF) shifts toward higher blood pressure levels. Angiotensin-converting enzyme (ACE) inhibitors reduce blood pressure and shift the autoregulation curve back to normal in hypertensive patients. ACE inhibitors have 2 major pharmacological properties: they inhibit both the production of angiotensin II and the breakdown of kinins. Hence, we investigated whether the effect of an ACE inhibitor on the lower limit of CBF autoregulation is mediated by the potentiation of bradykinin-mediated vasodilatation. Methods - In 28 male Sprague-Dawley rats, CBF was measured by laser-Doppler flowmetry during stepwise controlled hypotension. The lower limit of CBF autoregulation was defined as the mean arterial pressure at which CBF decreased by 20% of the baseline value. The rats were treated with an ACE inhibitor, captopril, in the captopril group; a bradykinin BK2-receptor antagonist, Hoe140, in the Hoe140 group; and both agents in the captopril+Hoe140 group. Other rats served as a control group. The lower limits of CBF autoregulation were compared among the 4 groups. Results - In the captopril group, the lower limit of CBF autoregulation was 43±8 mm Hg (mean±SD), which was significantly lower than that in the control group (57±14 mm Hg). Inhibition of bradykinin abolished the effect of captopril on the lower limit of CBF autoregulation. Hoe140 alone had no significant effect on the lower limit of CBF autoregulation. Conclusions - These results suggest that the shift of the lower limit of CBF autoregulation by captopril is mediated, at least in part, by bradykinin.

本文言語英語
ページ(範囲)1216-1219
ページ数4
ジャーナルStroke
32
5
DOI
出版ステータス出版済み - 2001

All Science Journal Classification (ASJC) codes

  • 臨床神経学
  • 循環器および心血管医学
  • 高度および特殊看護

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