Brain abscess due to infection with dematiaceous fungi cladophialophora bantiana associated with hypogammaglobulinemia following gastrectomy: A case report

Takafumi Shimogawa, Tetsuro Sayama, Sei Haga, Tomoaki Akiyama, Kosuke Makihara, Takato Morioka

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Dematiaceous fungi have melanin-like pigment in the cell wall and usually cause a variety of dermal infections in humans. Infections of the central nervous system (cerebral phaeohypho-mycosis) are rare but serious, since they commonly occur in immunocompromized patients. A 76-year-old man was admitted with mild motor aphasia and underwent total excision of a mass in the left frontal lobe. With the postoperative diagnosis of brain abscess due to infection with dematiaceous fungi (C. bantiana) associated with hypogammaglobulinemia following gastrec-tomy, intravenous antifungal drugs including amphotericin B and fluconazole were administered. Regrawth of the abscess with intraventricular rupture was noted at about the 88th day after the initial surgery, and the patient underwent neuroendoscopic aspiration of the pus and placement of a ventricular drain. Following intraventricular administration of miconazole through ventricular drainage or an Ommaya reservoir, neuroradiological findings improved, but general and neurological conditions worsened. Further treatment was discontinued and the patient died 9 months after onset. The poor outcome in this patient is attributed to 1) intractability of dematiaceous fungi, 2) development of ventriculitis and the need for intraventricular administration of antifungal drugs, and 3) untreatable hypogammaglobulinemia following gastrectomy.

本文言語英語
ページ(範囲)59-66
ページ数8
ジャーナルNeurological Surgery
44
1
出版ステータス出版済み - 1 2016

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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