Brain-derived mast cells could mediate histamine-induced inhibition of food intake in neonatal chicks

Shin Ichi Kawakami, Takashi Bungo, Atsushi Ohgushi, Ryuichi Ando, Masataka Shimojo, Yasuhisa Masuda, D. Michael Denbow, Mitsuhiro Furuse

研究成果: ジャーナルへの寄稿学術誌査読

28 被引用数 (Scopus)


In the present study, the effect of intracerebroventricular (i.c.v.) administration of histamine on food intake of neonatal chicks was examined over 2 h. Histamine (100, 200 or 400 nmol, respectively) was injected in the lateral ventricle of 2-day-old chicks, and cumulative food intakes were measured. i.c.v. injection of histamine significantly inhibited food intake in a dose-dependent manner. In addition, compound 48/80, which causes degranulation of mast cells and release of histamine, or thioperamide, which is an antagonist of the histamine H3 autoreceptor and increases histamine release from histaminergic nerve terminals, was injected i.c.v. to clarify whether mast cell- or neuron-derived histamine in the central nervous system of chicks is essential to the feeding inhibition. Central administration of compound 48/80 inhibited food intake with a dose-dependent manner, but thioperamide had no effect on feeding. An inhibitor of mast cell degranulation, sodium cromoglycate, somewhat attenuated food intake inhibited by compound 48/80. These results suggest that brain-derived mast cells could be a major source of histamine in the inhibition of food intake of neonatal chicks. Copyright (C) 2000 Elsevier Science B.V.

ジャーナルBrain Research
出版ステータス出版済み - 2月 28 2000

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学


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