Brain redox imaging

Ken Ichiro Matsumoto, Fuminori Hyodo, Kazunori Anzai, Hideo Utsumi, James B. Mitchell, Murali C. Krishna

    研究成果: Chapter in Book/Report/Conference proceedingChapter

    15 被引用数 (Scopus)

    抄録

    Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood-brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.

    本文言語英語
    ホスト出版物のタイトルMagnetic Resonance Neuroimaging
    ホスト出版物のサブタイトルMethods and Protocols
    編集者Michel Modo, Jelte Bulte
    ページ397-419
    ページ数23
    DOI
    出版ステータス出版済み - 2010

    出版物シリーズ

    名前Methods in Molecular Biology
    711
    ISSN(印刷版)1064-3745

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Genetics

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