Branched oligopeptides form nanocapsules with lipid vesicle characteristics

Pinakin Sukthankar, Sushanth Gudlur, L. Adriana Avila, Susan K. Whitaker, Benjamin B. Katz, Yasuaki Hiromasa, Jian Gao, Prem Thapa, David Moore, Takeo Iwamoto, Jianhan Chen, John M. Tomich

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

In a recent article (Gudlur et al. PLOS ONE, 2012, 7 (9) e45374), we described the special properties of a mixed branched peptide assembly in which equimolar bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK self-associate to form bilayer delimited capsules capable of trapping solutes. These polycationic vesicle-like capsules are readily taken up by epithelial cells in culture, escape or evade the endocytic pathway, and accumulate in the perinuclear region where they persist without any apparent degradation. In this report, we examine the lipidlike properties of this system including initial assembly; solute encapsulation and washing; fusion and resizing by membrane extrusion through polycarbonate filters with defined pore sizes. The resized peptide capsules have uniform diameters in nm size ranges. Once resized, the capsules can be maintained at the new size by storing them at 4 C. Having the ability to prepare stable uniform nanoscale capsules of desired sizes makes them potentially attractive as biocompatible delivery vehicles for various solutes/drugs.

本文言語英語
ページ(範囲)14648-14654
ページ数7
ジャーナルLangmuir
29
47
DOI
出版ステータス出版済み - 11 26 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 材料科学(全般)
  • 凝縮系物理学
  • 表面および界面
  • 分光学
  • 電気化学

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