Breakdown of Bruch's Membrane after Subretinal Injection of Vitreous: Role of Cellular Processes

Zhi Ren Zhu, Randi Goodnight, Tatsuro Ishibashi, Nino Sorgente, Thomas E. Ogden, Stephen J. Ryan

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)

抄録

It was recently shown that the injection of autologous vitreous beneath the retina of rabbits leads to retinal degeneration, subretinal cellular proliferation and neovascularization. The current study, using electron microscopy, was designed to determine the cellular processes involved in the breakdown of Bruch's membrane in this model. Bruch's membrane was not mechanically damaged by the injection and appeared intact for the first 1 to 2 days after injection. Subsequently, numerous breaks in Bruch's membrane were found associated with invasion of macrophages and fibroblasts; in addition, budding and penetration of retinal pigment epithelial (RPE) and choroidal endothelial cells into Bruch's membrane were noted. Although it was not proven that these cells, per se, were responsible for the breaks, that these cells actively penetrate Bruch's membrane is a reasonable hypothesis.

本文言語英語
ページ(範囲)925-929
ページ数5
ジャーナルOphthalmology
95
7
DOI
出版ステータス出版済み - 1988
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 眼科学

フィンガープリント

「Breakdown of Bruch's Membrane after Subretinal Injection of Vitreous: Role of Cellular Processes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル