Bronchoscopic findings for bevacizumab-related pulmonary hemorrhage in advanced non-small cell lung cancer

Kunio Okamoto, Isamu Okamoto, Masaki Miyazaki, Kaoru Tanaka, Hiroyasu Kaneda, Kazuhiko Nakagawa

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

We report contemporaneous bronchoscopic findings for a case of bevacizumab-related pulmonary hemorrhage in a patient with advanced non-small cell lung cancer (NSCLC). Flexible bronchoscopy at diagnosis revealed abnormal capillary dilation that was suggestive of endobronchial involvement at the primary tumor location. The patient developed massive hemoptysis despite of marked tumor shrinkage achieved by bevacizumab-containing chemotherapy. Emergency flexible bronchoscopy for hemoptysis suggested that the location of the primary tumor was the source of bleeding. Subsequent follow-up flexible bronchoscopy revealed an ulcerative mucosal-like lesion associated with a white necrotic substance as well as attenuation of the dilation of submucosal vessels compared with that apparent at diagnosis. Our case report highlights the potential mechanistic insights into bevacizumab-related bleeding and importance of performing bronchoscopy at diagnosis in NSCLC patients, given that abnormal bronchoscopic findings may be a risk factor for bleeding.

本文言語英語
ページ(範囲)1364-1366
ページ数3
ジャーナルInvestigational New Drugs
31
5
DOI
出版ステータス出版済み - 10 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 薬理学
  • 薬理学(医学)

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