抄録
Background/Aim: Budding uninhibited by benzimidazole-related 1 (BUBR1) plays an important role in the spindle assembly checkpoint to prevent chromosome missegregation and aneuploidy during mitosis. We previously generated mutant mice that express BUBR1 at only 20% of the normal level (BubR1L/L mice). Here, we examined the effect of low BUBR1 expression on oxidative stress-induced carcinogenesis in mice. Materials and Methods: We orally administered either a potassium bromate (KBrO3) solution (2 g/l) or tap water to BubR1L/L and wild-type (BubR1+/+) mice for 16 weeks and examined the subsequent incidence of tumours. Results: KBrO3-treated BubR1L/L mice showed significantly higher mortality than the KBrO3-treated BubR1+/+ and control tap water-treated mice (p=0.0082). Histopathological and immunohistochemical analyses revealed that the spleens of surviving BubR1L/L mice were occupied by non-B-, non-T-cells with high proliferative potential. Conclusion: Our results indicate that low BUBR1 expression increases oxidative stress-induced mortality in mice, possibly caused by splenic neoplasms.
本文言語 | 英語 |
---|---|
ページ(範囲) | 769-776 |
ページ数 | 8 |
ジャーナル | In Vivo |
巻 | 30 |
号 | 6 |
DOI | |
出版ステータス | 出版済み - 11月 1 2016 |
!!!All Science Journal Classification (ASJC) codes
- 生化学、遺伝学、分子生物学(全般)
- 薬理学