Bullous pemphigoid: What's ahead?

Masutaka Furue, Takafumi Kadono

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disease mainly affecting older individuals. Pathogenic autoantibodies preferentially target the non-collagenous 16A domain of collagen XVII (also called BP antigen 2, BPAG2) present in hemidesmosomes. The pathogenic anti-BPAG2 antibodies cause the dermal-epidermal separation in neonatal and adult mice as well as in cryosections of human skin. These experimental BP models stress a pivotal role for neutrophils and the Fcγ receptor of immunoglobulins. Mice that have been genetically manipulated in the pathogenic domain of BPAG2 spontaneously develop subepidermal blistering with pruritus and eosinophilic infiltration. BPAG2 is physiologically and aberrantly expressed in neuronal tissue and internal malignancies, and the associations of BP with Parkinson's disease, stroke and internal malignancies invites new investigations into the immunological dysregulation behind the comorbidity.

元の言語英語
ページ(範囲)237-240
ページ数4
ジャーナルJournal of Dermatology
43
発行部数3
DOI
出版物ステータス出版済み - 3 1 2016

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Bullous Pemphigoid
Antigens
Hemidesmosomes
Immunoglobulin Fc Fragments
Skin
Fc Receptors
Pruritus
Skin Diseases
Autoantibodies
Parkinson Disease
Comorbidity
Neoplasms
Neutrophils
Stroke
Antibodies

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Bullous pemphigoid : What's ahead? / Furue, Masutaka; Kadono, Takafumi.

:: Journal of Dermatology, 巻 43, 番号 3, 01.03.2016, p. 237-240.

研究成果: ジャーナルへの寄稿評論記事

Furue, Masutaka ; Kadono, Takafumi. / Bullous pemphigoid : What's ahead?. :: Journal of Dermatology. 2016 ; 巻 43, 番号 3. pp. 237-240.
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