Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children

Takashi Furuta, Shunji Hasegawa, Makoto Mizutani, Takashi Iwai, Noriko Ohbuchi, Shoji Kawano, Norimichi Tashiro, Masashi Uchida, Masanari Hasegawa, Masashi Motoyama, Takaomi Sekino, Kenji Nakatsuka, Kiyoshi Ichihara, Komei Shirabe, Shoichi Ohga

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study was to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n = 114) or RSV (n = 1,103) infection in Yamaguchi prefecture, Japan, between 2011 and 2014 were enrolled. Bronchial asthma was defined as having more than 3 episodes of wheezing illness over 1 year of age. Infection was determined by the positive antigen test for each virus in the nasal specimens. RESULTS: The number of patients peaked at age 12-15 months in hMPV infection and at age 0-3 months in RSV infection. The proportion of hypoxic patients (40-50%) did not differ at any age between hMPV-infected and RSV-infected children. In the analysis of date from > 1 year old patients with hypoxia, hMPV-infection group was older (P = 0.036), and more frequently had history of asthma (P = 0.015) or abnormal chest roentgenogram (P < 0.001) than RSV-infection group. Multivariate analysis indicated that the hypoxia-associated factors were history of asthma in both hMPV (odds ratio [OR]: 15.8; P < 0.001) and RSV infections (OR, 2.2; P = 0.005), higher body temperature in hMPV infection (OR, 2.2; P = 0.009), and younger age in RSV infection (OR, 1.4; P = 0.004). CONCLUSIONS: Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children.

元の言語英語
ページ(範囲)1107-1111
ページ数5
ジャーナルThe Pediatric infectious disease journal
37
発行部数11
DOI
出版物ステータス出版済み - 11 1 2018

Fingerprint

Human respiratory syncytial virus
Metapneumovirus
Respiratory Syncytial Virus Infections
Infection
Odds Ratio
Respiratory Syncytial Viruses
Asthma
Disease Outbreaks
Respiratory Sounds
Body Temperature
Nose
Respiratory Tract Infections
Inpatients
Japan
Thorax
Multivariate Analysis
Pediatrics
Viruses
Antigens

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

これを引用

Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children. / Furuta, Takashi; Hasegawa, Shunji; Mizutani, Makoto; Iwai, Takashi; Ohbuchi, Noriko; Kawano, Shoji; Tashiro, Norimichi; Uchida, Masashi; Hasegawa, Masanari; Motoyama, Masashi; Sekino, Takaomi; Nakatsuka, Kenji; Ichihara, Kiyoshi; Shirabe, Komei; Ohga, Shoichi.

:: The Pediatric infectious disease journal, 巻 37, 番号 11, 01.11.2018, p. 1107-1111.

研究成果: ジャーナルへの寄稿記事

Furuta, T, Hasegawa, S, Mizutani, M, Iwai, T, Ohbuchi, N, Kawano, S, Tashiro, N, Uchida, M, Hasegawa, M, Motoyama, M, Sekino, T, Nakatsuka, K, Ichihara, K, Shirabe, K & Ohga, S 2018, 'Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children', The Pediatric infectious disease journal, 巻. 37, 番号 11, pp. 1107-1111. https://doi.org/10.1097/INF.0000000000002038
Furuta, Takashi ; Hasegawa, Shunji ; Mizutani, Makoto ; Iwai, Takashi ; Ohbuchi, Noriko ; Kawano, Shoji ; Tashiro, Norimichi ; Uchida, Masashi ; Hasegawa, Masanari ; Motoyama, Masashi ; Sekino, Takaomi ; Nakatsuka, Kenji ; Ichihara, Kiyoshi ; Shirabe, Komei ; Ohga, Shoichi. / Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children. :: The Pediatric infectious disease journal. 2018 ; 巻 37, 番号 11. pp. 1107-1111.
@article{edcaa6afbbc842058756c0c078dc8a31,
title = "Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children",
abstract = "BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study was to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n = 114) or RSV (n = 1,103) infection in Yamaguchi prefecture, Japan, between 2011 and 2014 were enrolled. Bronchial asthma was defined as having more than 3 episodes of wheezing illness over 1 year of age. Infection was determined by the positive antigen test for each virus in the nasal specimens. RESULTS: The number of patients peaked at age 12-15 months in hMPV infection and at age 0-3 months in RSV infection. The proportion of hypoxic patients (40-50{\%}) did not differ at any age between hMPV-infected and RSV-infected children. In the analysis of date from > 1 year old patients with hypoxia, hMPV-infection group was older (P = 0.036), and more frequently had history of asthma (P = 0.015) or abnormal chest roentgenogram (P < 0.001) than RSV-infection group. Multivariate analysis indicated that the hypoxia-associated factors were history of asthma in both hMPV (odds ratio [OR]: 15.8; P < 0.001) and RSV infections (OR, 2.2; P = 0.005), higher body temperature in hMPV infection (OR, 2.2; P = 0.009), and younger age in RSV infection (OR, 1.4; P = 0.004). CONCLUSIONS: Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children.",
author = "Takashi Furuta and Shunji Hasegawa and Makoto Mizutani and Takashi Iwai and Noriko Ohbuchi and Shoji Kawano and Norimichi Tashiro and Masashi Uchida and Masanari Hasegawa and Masashi Motoyama and Takaomi Sekino and Kenji Nakatsuka and Kiyoshi Ichihara and Komei Shirabe and Shoichi Ohga",
year = "2018",
month = "11",
day = "1",
doi = "10.1097/INF.0000000000002038",
language = "English",
volume = "37",
pages = "1107--1111",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children

AU - Furuta, Takashi

AU - Hasegawa, Shunji

AU - Mizutani, Makoto

AU - Iwai, Takashi

AU - Ohbuchi, Noriko

AU - Kawano, Shoji

AU - Tashiro, Norimichi

AU - Uchida, Masashi

AU - Hasegawa, Masanari

AU - Motoyama, Masashi

AU - Sekino, Takaomi

AU - Nakatsuka, Kenji

AU - Ichihara, Kiyoshi

AU - Shirabe, Komei

AU - Ohga, Shoichi

PY - 2018/11/1

Y1 - 2018/11/1

N2 - BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study was to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n = 114) or RSV (n = 1,103) infection in Yamaguchi prefecture, Japan, between 2011 and 2014 were enrolled. Bronchial asthma was defined as having more than 3 episodes of wheezing illness over 1 year of age. Infection was determined by the positive antigen test for each virus in the nasal specimens. RESULTS: The number of patients peaked at age 12-15 months in hMPV infection and at age 0-3 months in RSV infection. The proportion of hypoxic patients (40-50%) did not differ at any age between hMPV-infected and RSV-infected children. In the analysis of date from > 1 year old patients with hypoxia, hMPV-infection group was older (P = 0.036), and more frequently had history of asthma (P = 0.015) or abnormal chest roentgenogram (P < 0.001) than RSV-infection group. Multivariate analysis indicated that the hypoxia-associated factors were history of asthma in both hMPV (odds ratio [OR]: 15.8; P < 0.001) and RSV infections (OR, 2.2; P = 0.005), higher body temperature in hMPV infection (OR, 2.2; P = 0.009), and younger age in RSV infection (OR, 1.4; P = 0.004). CONCLUSIONS: Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children.

AB - BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study was to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n = 114) or RSV (n = 1,103) infection in Yamaguchi prefecture, Japan, between 2011 and 2014 were enrolled. Bronchial asthma was defined as having more than 3 episodes of wheezing illness over 1 year of age. Infection was determined by the positive antigen test for each virus in the nasal specimens. RESULTS: The number of patients peaked at age 12-15 months in hMPV infection and at age 0-3 months in RSV infection. The proportion of hypoxic patients (40-50%) did not differ at any age between hMPV-infected and RSV-infected children. In the analysis of date from > 1 year old patients with hypoxia, hMPV-infection group was older (P = 0.036), and more frequently had history of asthma (P = 0.015) or abnormal chest roentgenogram (P < 0.001) than RSV-infection group. Multivariate analysis indicated that the hypoxia-associated factors were history of asthma in both hMPV (odds ratio [OR]: 15.8; P < 0.001) and RSV infections (OR, 2.2; P = 0.005), higher body temperature in hMPV infection (OR, 2.2; P = 0.009), and younger age in RSV infection (OR, 1.4; P = 0.004). CONCLUSIONS: Outbreaks of hMPV, rather than, RSV infection may have a greater impact on the development of hypoxic respiratory illness in asthmatic children.

UR - http://www.scopus.com/inward/record.url?scp=85054743493&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054743493&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000002038

DO - 10.1097/INF.0000000000002038

M3 - Article

VL - 37

SP - 1107

EP - 1111

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 11

ER -