C-C Bond Cleavage of Unactivated 2-Acylimidazoles

Hai Long Xin, Bo Pang, Jeesoo Choi, Walaa Akkad, Hiroyuki Morimoto, Takashi Ohshima

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

2-Acylimidazoles are widely used as post-Transformable carboxylic acid equivalents in chemoselective and enantioselective reactions. Their transformations, however, require pretreatment with highly reactive, toxic methylating reagents to facilitate C-C bond cleavage. Here, we demonstrate that such pretreatment can be avoided and the C-C bond cleaved under neutral conditions without the use of additional reagents or catalysts. The scope of the reaction, including the use of products reported in the literature as substrates, and some mechanistic insights are described.

本文言語英語
ページ(範囲)11592-11606
ページ数15
ジャーナルJournal of Organic Chemistry
85
18
DOI
出版ステータス出版済み - 9 18 2020

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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