C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma

T. Matsumoto, S. Itoh, T. Yoshizumi, T. Kurihara, S. Yoshiya, Yohei Mano, kazuki takeishi, N. Harada, T. Ikegami, Y. Soejima, H. Baba, M. Mori

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)

抄録

Background: The C-reactive protein : albumin ratio (CAR) has been reported as a novel prognostic marker in several cancers. The aim of this study was to investigate the prognostic value of CAR in patients with intrahepatic cholangiocarcinoma (ICC). Methods: This was a single-centre retrospective study of patients who underwent surgery for ICC in a university hospital in Japan between 1998 and 2018. CAR, Glasgow Prognostic Score (GPS) and modified GPS (mGPS) were calculated. Their correlation with recurrence-free survival (RFS) and overall survival (OS) was analysed with Cox proportional hazards models. Results: Seventy-two patients were included in the study. Patients were divided into two groups according to the optimal CAR cut-off value of 0·02. CAR above 0·02 was associated with higher carbohydrate antigen 19-9 levels (20·5 versus 66·1 units/ml for CAR of 0·02 or less; P = 0·002), larger tumour size (3·2 versus 4·4 cm respectively; P = 0·031) and a higher rate of microvascular invasion (9 of 28 versus 25 of 44; P = 0·041). RFS and OS were shorter in patients with CAR above 0·02: hazard ratio (HR) 4·31 (95 per cent c.i. 2·02 to 10·63) and HR 4·80 (1·85 to 16·40) respectively. In multivariable analysis CAR above 0·02 was an independent prognostic factor of RFS (HR 3·29 (1·33 to 8·12); P < 0·001), but not OS. Conclusions: CAR was associated with prognosis in patients who had hepatic resection for ICC.

本文言語英語
ページ(範囲)1146-1152
ページ数7
ジャーナルBJS open
4
6
DOI
出版ステータス出版済み - 12月 2020

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

フィンガープリント

「C-reactive protein: albumin ratio in patients with resectable intrahepatic cholangiocarcinoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル