Ca release in the endoplasmic reticulum of Guinea pig peritoneal macrophages 1

Masato Hirata, Takafumi Hamachi, Toshihiko Hashimoto, Eiichi Suematsu, Toshitaka Koga

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

Passive permeability of the endoplasmic reticulum of saponin-treated macrophages to Ca 2+ was studied by the filtration method using 45 Ca. The Ca 2+ release from the endoplasmic reticulum of macrophages was enhanced by the presence of submicromolar concentrations of Ca 2+ in the medium. The Ca 2+ release was enhanced by caffeine, and suppressed by MgCl 2 . These phenomena are similar to the Ca 2+ -induced Ca 2+ release reported for the sarcoplasmic reticulum of skeletal muscle. On the other hand, adenine suppressed the Ca 2+ release from the endoplasmic reticulum, while it reportedly enhanced the Ca 2+ -induced Ca 2+ release of the skeletal muscle. The threshold concentration of Ca 2+ for the Ca 2+ -induced Ca 2+ release was approximately 10 -8 M in the presence of 0.95 mM MgCl 2 in macrophages. The spontaneous spreading of macrophages and spontaneous migration of macrophages were inhibited by adenine, and also by caffeine in spite of the enhancement of the Ca 2+ -induced Ca 2+ release.

本文言語英語
ページ(範囲)1155-1163
ページ数9
ジャーナルJournal of biochemistry
94
4
DOI
出版ステータス出版済み - 1 1 1983

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学

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