CAD scheme for detection of intracranial aneurysms in MRA based on 3D analysis of vessel skeletons and enhanced aneurysms

Hidetaka Arimura, Qiang Li, Yukunori Korogi, Toshinori Hirai, Yasuyuki Yamashita, Shigehiko Katsuragawa, Ryuji Ikeda, Kunio Doi

研究成果: ジャーナルへの寄稿会議記事査読

2 被引用数 (Scopus)


We have developed a computer-aided diagnostic (CAD) scheme for detection of unruptured intracranial aneurysms in magnetic resonance angiography (MRA) based on findings of short branches in vessel skeletons, and a three-dimensional (3D) selective enhancement filter for dots (aneurysms). Fifty-three cases with 61 unruptured aneurysms and 62 non-aneurysm cases were tested in this study. The Isotropic 3D MRA images with 400 × 400 × 128 voxels (a voxel size of 0.5 mm) were processed by use of the dot enhancement filter. The initial candidates were identified not only on the dot-enhanced images by use of a multiple gray-level thresholding technique, but also on the vessel skeletons by finding short branches on parent skeletons, which can indicate a high likelihood of small aneurysms. All candidates were classified into four categories of candidates according to effective diameter and local structure of the vessel skeleton. In each category, a number of false positives were removed by use of two rule-based schemes and by linear discriminant analysis on localized image features related to gray level and morphology. Our CAD scheme achieved a sensitivity of 97% with 5.0 false positives per patient by use of a leave-one-out-by-patient test method. This CAD system may be useful in assisting radiologists in the detection of small intracranial aneurysms as well as medium-size aneurysms in MRA.

ジャーナルProgress in Biomedical Optics and Imaging - Proceedings of SPIE
出版ステータス出版済み - 2005
イベントMedical Imaging 2005 - Image Processing - San Diego, CA, 米国
継続期間: 2月 13 20052月 17 2005

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 原子分子物理学および光学
  • 放射線学、核医学およびイメージング


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