Calcium channel in isolated outer hair cells of guinea pig cochlea

T. Nakagwa, S. Kakehata, N. Akaike, S. Komune, T. Takasaka, T. Uemura

研究成果: Contribution to journalArticle査読

61 被引用数 (Scopus)

抄録

The physiological and pharmacological properties of the Ca2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca2+ current (ICa) was activated from a membrane potential of -20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca2+ at a holding potential of -70 mV. The peak amplitude of ICa increased in a hyperbolic manner with increasing extracellular Ca2+ concentration. The ion selectively was Ba2+ > > Ca2+ ≥Sr2+. It was concluded that the Ca2+ channel in OHCs of guinea pig is of the L-type.

本文言語英語
ページ(範囲)81-84
ページ数4
ジャーナルNeuroscience Letters
125
1
DOI
出版ステータス出版済み - 4 15 1991

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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