Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat

Tomomi Shindou, Shigenori Watanabe, Osamu Kamata, Kenji Yamamoto, Hiroshi Nakanishi

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

The physiological profiles contributing to hyperexcitability of hippocampal CA1 neurons following ethanol withdrawal (EW) were examined in an in vitro slice preparation obtained from EW rats. Sixty-two percent of CA1 neurons in slices from EW rats exhibited intrinsic burst property which was rarely observed in those from control animals. The mean duration of plateau component of calcium (Ca) spikes was significantly increased after EW. The burst response evoked by either synaptic or direct stimulation in hippocampal CA1 neurons from EW rats was markedly depressed by high Mg solution but not by flunarizine. Furthermore, 6-cyano-7-nitroquinoxaline-2,3-dione, a non-NMDA receptor antagonist, markedly depressed the synaptically evoked burst response, while [(±)-2-carboxypiperazine-4-yl-]-propyl-1-phosphonic acid, a selective N-methyl-d-aspartate (NMDA) receptor antagonist, slightly delayed the onset of the response. The results indicate that an increase in the number of bursting hippocampal CA1 neurons associated with an augmentation of the plateau component of Ca spike contributes to the genesis of hyperexcitability in EW rats. Furthermore, non-NMDA receptor-mediated EPSP is mainly responsible for a synaptic induction of the burst response. These results are consistent with the involvement of high-threshold Ca channels in EW hyperexcitability.

本文言語英語
ページ(範囲)432-436
ページ数5
ジャーナルBrain Research
656
2
DOI
出版ステータス出版済み - 9 12 1994

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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