Calcium molybdate nanoparticles formation in egg phosphatidyl choline based liposome caused by liposome fusion

Shinya Yamasaki, Saori Kurita, Asumi Ochiai, Miya Hashimoto, Keisuke Sueki, Satoshi Utsunomiya

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

In order to achieve the highly efficient 99mTc production from 100MoO3 by the 100Mo(n, 2n)99Mo reaction, we have developed a new protocol to synthesize nano-sized Mo particles, of which the size was controlled by the inner space of the liposomes. Calcium and molybdate ions were encapsulated into ∼100 nm size liposomes. The liposome suspensions were then mixed and heated to promote the membrane fusion. As a result, the insoluble CaMoO4 nanoparticles precipitated inside the liposomes. The median particle diameter of 168 nm and average diameter of 169 ± 56 nm (n = 109) were obtained from an SEM image, and the particles have a powellite-structure. The formation process of the particles was then examined. The formation of nano-sized CaMoO4 was observed by the high resolution TEM image and TEM image of negative-stained liposome. At the room temperature, the fusion of liposome did not occur significantly. These results suggest that nanocrystals of the CaMoO4 were likely formed in the liposomes because of the liposome fusion and aggregated during the drying processes of reaction solution.

本文言語英語
ページ(範囲)473-480
ページ数8
ジャーナルJournal of Colloid And Interface Science
530
DOI
出版ステータス出版済み - 11 15 2018

All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 表面、皮膜および薄膜
  • コロイド化学および表面化学

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