Calmodulin antagonists inhibit Ca2+ uptake of mitochondria of guinea pig peritoneal macrophages

Masato Hirata, Eiichi Suematsu, Toshitaka Koga

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

The Ca2+ uptake of the mitochondria of guinea pig peritoneal macrophages was not stimulated by the addition of calmodulin. However, calmodulin antagonists, both phenotiazines and N-naphthalenesulfonamides, in low concentrations inhibited the Ca2+ uptake of the mitochondoria, as compared to the inhibition of the calmodulin-dependent stimulation of brain phosphodiesterase. These calmodulin antagonists appear to have severe side effects on active processes of the mitochondria and which are unrelated to the specific effect on calmodulin.

本文言語英語
ページ(範囲)1176-1181
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
105
3
DOI
出版ステータス出版済み - 4 14 1982

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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