Calorie restriction minimizes activation of insulin signaling in response to glucose: Potential involvement of the growth hormone-insulin-like growth factor 1 axis

Hiroko Hayashi, Haruyoshi Yamaza, Toshimitsu Komatsu, Seongjoon Park, Takuya Chiba, Yoshikazu Higami, Takeshi Nagayasu, Isao Shimokawa

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Calorie restriction (CR) may modulate insulin signaling in response to energy intake through suppression of the growth hormone (GH)-IGF-1 axis. We investigated the glucose-stimulated serum insulin response and subsequent alterations in insulin receptor (IR), Akt, and FoxO1 in the rat liver and quadriceps femoris muscle (QFM). Nine-month-old wild-type (W) male Wistar rats fed ad libitum (AL) or a 30% CR diet initiated at 6 weeks of age and GH-suppressed transgenic (Tg) rats fed AL were killed 15 min after intraperitoneal injection of glucose or saline. In W-AL rats, the serum insulin concentration was elevated by glucose injection. Concomitantly, the phosphorylated (p)-IR and p-Akt levels were increased in both tissues. The active FoxO1 level was decreased in the liver, but not significantly in the QFM. In W-CR and Tg-AL rats, the serum insulin response was lower, and no significant changes were noted for the p-IR, p-Akt, or active FoxO1 levels in the liver. In the QFM, the p-Akt level was increased in W-CR and Tg-AL rats with an insignificant elevation of p-IR levels. The phenotypic similarity of W-CR and Tg-AL rats suggest that CR minimizes activation of insulin signaling in response to energy intake mostly through the GH-IGF-1 axis.

元の言語英語
ページ(範囲)827-832
ページ数6
ジャーナルExperimental Gerontology
43
発行部数9
DOI
出版物ステータス出版済み - 9 1 2008

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Quadriceps Muscle
Somatomedins
Growth Hormone
Rats
Chemical activation
Insulin Receptor
Insulin
Glucose
Liver
Muscle
Energy Intake
Insulin-Like Growth Factor I
Serum
Transgenic Rats
Intraperitoneal Injections
Nutrition
Wistar Rats
Diet
Injections
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

これを引用

Calorie restriction minimizes activation of insulin signaling in response to glucose : Potential involvement of the growth hormone-insulin-like growth factor 1 axis. / Hayashi, Hiroko; Yamaza, Haruyoshi; Komatsu, Toshimitsu; Park, Seongjoon; Chiba, Takuya; Higami, Yoshikazu; Nagayasu, Takeshi; Shimokawa, Isao.

:: Experimental Gerontology, 巻 43, 番号 9, 01.09.2008, p. 827-832.

研究成果: ジャーナルへの寄稿記事

Hayashi, Hiroko ; Yamaza, Haruyoshi ; Komatsu, Toshimitsu ; Park, Seongjoon ; Chiba, Takuya ; Higami, Yoshikazu ; Nagayasu, Takeshi ; Shimokawa, Isao. / Calorie restriction minimizes activation of insulin signaling in response to glucose : Potential involvement of the growth hormone-insulin-like growth factor 1 axis. :: Experimental Gerontology. 2008 ; 巻 43, 番号 9. pp. 827-832.
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