Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients

Nobutoshi Kawamura, Hua Piao, Motozumi Minohara, Takuya Matsushita, Susumu Kusunoki, Hiroshi Matsumoto, Kazuhiro Ikenaka, Yoshimitsu Mizunoe, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barré syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.

元の言語英語
ページ(範囲)74-78
ページ数5
ジャーナルJournal of Neuroimmunology
240-241
DOI
出版物ステータス出版済み - 12 15 2011

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Campylobacter jejuni
DNA-Binding Proteins
Sulfoglycosphingolipids
Enteritis
Myelin Sheath
Serum
Peripheral Nerves
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

これを引用

Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients. / Kawamura, Nobutoshi; Piao, Hua; Minohara, Motozumi; Matsushita, Takuya; Kusunoki, Susumu; Matsumoto, Hiroshi; Ikenaka, Kazuhiro; Mizunoe, Yoshimitsu; Kira, Jun-Ichi.

:: Journal of Neuroimmunology, 巻 240-241, 15.12.2011, p. 74-78.

研究成果: ジャーナルへの寄稿記事

Kawamura, Nobutoshi ; Piao, Hua ; Minohara, Motozumi ; Matsushita, Takuya ; Kusunoki, Susumu ; Matsumoto, Hiroshi ; Ikenaka, Kazuhiro ; Mizunoe, Yoshimitsu ; Kira, Jun-Ichi. / Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients. :: Journal of Neuroimmunology. 2011 ; 巻 240-241. pp. 74-78.
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abstract = "Campylobacter jejuni enteritis is frequently associated with an axonal form of Guillain-Barr{\'e} syndrome (GBS) and C. jejuni DNA-binding protein from starved cells (C-Dps) induces paranodal myelin detachment and axonal degeneration through binding with sulfatide in vivo. Here we investigated the invasion of C-Dps into hosts with C. jejuni-related GBS. Our analyses of patient sera found that both C-Dps and anti-C-Dps antibodies were most commonly detected in sera from C. jejuni-related GBS patients (5/27, 14.8{\%} and 15/24, 62.5{\%}; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS.",
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AU - Piao, Hua

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AU - Kusunoki, Susumu

AU - Matsumoto, Hiroshi

AU - Ikenaka, Kazuhiro

AU - Mizunoe, Yoshimitsu

AU - Kira, Jun-Ichi

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