Can chromosomal instability initiate tumorigenesis?

Franziska Michor, Yoh Iwasa, Bert Vogelstein, Christoph Lengauer, Martin A. Nowak

研究成果: ジャーナルへの寄稿評論記事

132 引用 (Scopus)

抄録

Cancers result from the accumulation of inherited and somatic mutations in oncogenes and tumor suppressor genes. These genes encode proteins that function in growth regulatory and differentiation pathways. Mutations in those genes increase the net reproductive rate of cells. Chromosomal instability (CIN) is a feature of most human cancers. Mutations in CIN genes increase the rate at which whole chromosomes or large parts of chromosomes are lost or gained during cell division. CIN causes an imbalance in chromosome number (aneuploidy) and an enhanced rate of loss of heterozygosity, which is an important mechanism of inactivating tumor suppressor genes. A crucial question of cancer biology is whether CIN is an early event and thus a driving force of tumorigenesis. Here we discuss mathematical models of situations where inactivation of one or two tumor suppressor genes is required for tumorigenesis. If two tumor suppressor genes have to be inactivated in rate-limiting steps, then CIN is likely to emerge before the inactivation of the first tumor suppressor gene.

元の言語英語
ページ(範囲)43-49
ページ数7
ジャーナルSeminars in Cancer Biology
15
発行部数1
DOI
出版物ステータス出版済み - 2 1 2005

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Chromosomal Instability
Tumor Suppressor Genes
Carcinogenesis
Chromosomes
Mutation
Neoplasms
Loss of Heterozygosity
Aneuploidy
Oncogenes
Cell Division
Genes
Theoretical Models
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Cancer Research

これを引用

Michor, F., Iwasa, Y., Vogelstein, B., Lengauer, C., & Nowak, M. A. (2005). Can chromosomal instability initiate tumorigenesis? Seminars in Cancer Biology, 15(1), 43-49. https://doi.org/10.1016/j.semcancer.2004.09.007

Can chromosomal instability initiate tumorigenesis? / Michor, Franziska; Iwasa, Yoh; Vogelstein, Bert; Lengauer, Christoph; Nowak, Martin A.

:: Seminars in Cancer Biology, 巻 15, 番号 1, 01.02.2005, p. 43-49.

研究成果: ジャーナルへの寄稿評論記事

Michor, F, Iwasa, Y, Vogelstein, B, Lengauer, C & Nowak, MA 2005, 'Can chromosomal instability initiate tumorigenesis?', Seminars in Cancer Biology, 巻. 15, 番号 1, pp. 43-49. https://doi.org/10.1016/j.semcancer.2004.09.007
Michor, Franziska ; Iwasa, Yoh ; Vogelstein, Bert ; Lengauer, Christoph ; Nowak, Martin A. / Can chromosomal instability initiate tumorigenesis?. :: Seminars in Cancer Biology. 2005 ; 巻 15, 番号 1. pp. 43-49.
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