Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges.

Dyah Laksmi Dewi, Hideshi Ishii, Yoshihiro Kano, Shinpei Nishikawa, Naotsugu Haraguchi, Daisuke Sakai, Taroh Satoh, Yuichiro Doki, Masaki Mori

研究成果: Contribution to journalReview article査読

17 被引用数 (Scopus)

抄録

A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technological developments have allowed a deeper understanding and characterization of CSCs. Even though the application of this theory to hematopoietic malignancies and solid tumors holds promise for new ways to treat cancer, it also brings some skepticism. Efficacious therapeutic approaches targeting the CSC population should be explored to overcome therapeutic failure and improve patient outcomes. This review will focus on the intrinsic and extrinsic regulation of CSCs, as well as the development of therapeutic approaches against CSCs, predominantly focusing on gastrointestinal malignancies.

本文言語英語
ページ(範囲)1145-1157
ページ数13
ジャーナルJournal of gastroenterology
46
10
DOI
出版ステータス出版済み - 10 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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