Candida catheter related-blood stream infection

Masako Kadowaki, Nobuyuki Shimono

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Candida catheter-related bloodstream infection (CRBSI) is a biofilm-related disease, which is usually refractory because antifungals show limited effect. With medical development and increase in number of compromised hosts, CRBSI became more frequent. Candida, which is one of the opportunistic pathogens, ranks the fourth causative organism of bacteremia. The onset of bacteremia is greatly associated with the presence of catheter. Repeated blood cultures and the central venous catheter CVC tip culture are done for the definitive diagnosis of Candida CRBSI. Additionally serological examinations such as (1→3)-beta-D-glucan and mannan antigen are also useful for early diagnosis. It is important for the appropriate treatment to remove CVC, which is an artificial contaminated material, and administer antifungals promptly. As to the choice of antifungals, we should also take into account the ability of antibiofilm effect of antifungals as well as immunological state of host including neutropenia, prior administration of azoles, isolated or estimated Candida species, sensitivity against antifungals, administration route, pharmacokinetics (bioavailability, metabolic and excretion pathway, distribution) and drug interaction. As to complication of Candida bacteremia, first we should check endophthalmitis, which occurs frequently and leads to the loss of eyesight, as well as infective endocarditis, arthritis, metastatic infections such as embolic pneumonia and suppurative thrombotic phlebitis of catheter insertion site. Lastly we emphasize that the appropriate treatment based on the character of Candida bacteremia and biofilm leads to favorable prognosis.

元の言語英語
ページ(範囲)1-14
ページ数14
ジャーナルJapanese Journal of Antibiotics
67
発行部数1
出版物ステータス出版済み - 2014

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Candida
Catheters
Bacteremia
Catheter-Related Infections
Infection
Biofilms
Mannans
Phlebitis
Azoles
beta-Glucans
Endophthalmitis
Central Venous Catheters
Metabolic Networks and Pathways
Endocarditis
Neutropenia
Drug Interactions
Biological Availability
Arthritis
Early Diagnosis
Pneumonia

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Candida catheter related-blood stream infection. / Kadowaki, Masako; Shimono, Nobuyuki.

:: Japanese Journal of Antibiotics, 巻 67, 番号 1, 2014, p. 1-14.

研究成果: ジャーナルへの寄稿評論記事

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