Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism

Kazuhide Hayakawa, Kenichi Mishima, Kohji Abe, Nobuyoshi Hasebe, Fumie Takamatsu, Hiromi Yasuda, Tomoaki Ikeda, Keiichiro Inui, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

抜粋

Cannabidiol, a non-psychoactive constituent of cannabis, has been reported as a neuroprotectant. Cannabidiol and Δ 9-tetrahydrocannabinol, the primary psychoactive constituent of cannabis, significantly decreased the infarct volume at 4 h in the mouse middle cerebral artery occlusion model. The neuroprotective effects of Δ 9-tetrahydrocannabinol but not cannabidiol were inhibited by SRI41716, a cannabinoid CBI receptor antagonist, and were abolished by warming of the animals to the levels observed in the controls. Δ 9-Tetrahydrocannabinol significantly decreased the rectal temperature, and the hypothermic effect was inhibited by SRI41716. These results surely show that the neuroprotective effect of Δ 9- tetrahydrocannabinol are via a CBI receptor and temperature-dependent mechanisms whereas the neuroprotective effects of cannabidiol are independent of CBI blockade and of hypothermia.

元の言語英語
ページ(範囲)2381-2385
ページ数5
ジャーナルNeuroReport
15
発行部数15
DOI
出版物ステータス出版済み - 10 25 2004
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Hayakawa, K., Mishima, K., Abe, K., Hasebe, N., Takamatsu, F., Yasuda, H., ... Fujiwara, M. (2004). Cannabidiol prevents infarction via the non-CBI cannabinoid receptor mechanism. NeuroReport, 15(15), 2381-2385. https://doi.org/10.1097/00001756-200410250-00016