Two marihuana constituents, cannabidiol (1) and cannabidiolic acid (4) were each converted mainly to two metabolites using tissue segments of Pinellia ternata tuber. The structures of the metabolites formed from 1 were determined to be 1-0-β-D-glucopyranoside and 1-0-β-D- diglucopyranoside by 1H nmr, 13C nmr and fabms. Those from 4 were determined as 4- 0- β-D- glucopyranoside and 10'-hydroxyl 4-0- βD-glucopyranoside. In time course experiments, 1 was absorbed rapidly by the tissues and glucosylated. Hydroxylation subsequent to the glucosylation occurred at the pentyl group in 4.
All Science Journal Classification (ASJC) codes
- Agronomy and Crop Science
- Plant Science