Canonical transient receptor potential channels and vascular smooth muscle cell plasticity

Motohiro Nishida, Tomohiro Tanaka, Supachoke Mangmool, Kazuhiro Nishiyama, Akiyuki Nishimura

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

Vascular smooth muscle cells (VSMCs) play a pivotal role in the stability and tonic regulation of vascular homeostasis. VSMCs can switch back and forth between highly proliferative (synthetic) and fully differentiated (contractile) phenotypes in response to changes in the vessel environment. Abnormal phenotypic switching of VSMCs is a distinctive characteristic of vascular disorders, including atherosclerosis, pulmonary hypertension, stroke, and peripheral artery disease; however, how the control of VSMC phenotypic switching is dysregulated under pathological conditions remains obscure. Canonical transient receptor potential (TRPC) channels have attracted attention as a key regulator of pathological phenotype switching in VSMCs. Several TRPC subfamily member proteins—especially TRPC1 and TRPC6—are upregulated in pathological VSMCs, and pharmacological inhibition of TRPC channel activity has been reported to improve hypertensive vascular remodeling in rodents. This review summarizes the current understanding of the role of TRPC channels in cardiovascular plasticity, including our recent finding that TRPC6 participates in aberrant VSMC phenotype switching under ischemic conditions, and discusses the therapeutic potential of TRPC channels.

本文言語英語
ページ(範囲)124-139
ページ数16
ジャーナルJournal of Lipid and Atherosclerosis
9
1
DOI
出版ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学
  • 内分泌学、糖尿病および代謝内科学
  • 内科学

フィンガープリント

「Canonical transient receptor potential channels and vascular smooth muscle cell plasticity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル