Capturing the mammalian hippo: Elucidating its role in cancer

Miki Nishio, Kohei Otsubo, Tomohiko Maehama, Koshi Mimori, Akira Suzuki

研究成果: ジャーナルへの寄稿評論記事

32 引用 (Scopus)

抜粋

The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.

元の言語英語
ページ(範囲)1271-1277
ページ数7
ジャーナルCancer Science
104
発行部数10
DOI
出版物ステータス出版済み - 10 1 2013

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Nishio, M., Otsubo, K., Maehama, T., Mimori, K., & Suzuki, A. (2013). Capturing the mammalian hippo: Elucidating its role in cancer. Cancer Science, 104(10), 1271-1277. https://doi.org/10.1111/cas.12227