Capturing the mammalian hippo: Elucidating its role in cancer

Miki Nishio, Kohei Otsubo, Tomohiko Maehama, Koshi Mimori, Akira Suzuki

研究成果: Contribution to journalReview article査読

36 被引用数 (Scopus)

抄録

The Hippo pathway is an evolutionarily conserved kinase cascade involved in cell growth, apoptosis, development and migration. It is also crucial for stem cell self-renewal and the maintenance of genomic stability. In addition, this pathway has the unique capacities to sense aspects of tissue architecture, such as cell polarity and mechanical tensions imposed by the surrounding microenvironment, and to control organ size and shape. All of these properties are frequently altered in tumor cells. In this review, we summarize how dysregulation of mammalian Hippo signaling is implicated in cancer.

本文言語英語
ページ(範囲)1271-1277
ページ数7
ジャーナルCancer Science
104
10
DOI
出版ステータス出版済み - 10 2013

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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